![]() Pfirrmann disc degeneration classification from lumbar MRI: grade I-IV.Imaging showed single-segment lumbar disc herniation.Symptoms and imaging showing unilateral lumbar disc herniation.CT/MRI clearly showing unilateral nucleus pulposus herniation to compress the nerve root.Failure of conservative treatments including physical therapy, manipulation therapy and non-morphine drug therapy.Symptoms with lower back pain and unilateral radicular pain.Lumbar disc signals will be also quantified using MRI to demonstrate hUCMSCs transplantation could slow down lumbar disc degeneration. Additionally, improvement of patients' quality of life will be evaluated using the ODI score, VAS score and SF-36 score. The patients will be followed up for 3 months, 6 months and 12 months after the injection to evaluate the safety of the patients after grafting hUCMSCs. Twenty million hUCMSCs will be injected into the lumbar disc of the enrolled patients in this non-random, self-controlled and single-dose open study design. This clinical trial is aimed to include a single group of 20 patients with lumbar disc herniation. To observe the safety and efficacy of human umbilical cord mesenchymal stem cells (hUCMSCs) in the treatment of lumbar disc degeneration. It is urgent to use stem cell and tissue engineering to replace the resection tissue and repair the residual nucleus pulposus for disc resealing. However, the reherniation of the residual nucleus pulposus still exist after nerve root decompression. In recent years, full endoscopic discectomy has been widely used in the treatment of lumbar disc herniation due to its advantages of reduced trauma, enhanced recovery and less cost. Lumbar disc herniation causes patients severe lower back pain and radicular pain to decrease the quality of life and lead to great economic burden to patients and society. Why Should I Register and Submit Results?.
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